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News 2

Pharmacogenetics

Polymorphisms of the ADRβ2 gene for the β2-adrenergic receptor
can influence clinical response to β agonists. For the ADRB2,

single nucleotide polymorphisms (SNPs) have been defined at codons 16and 27. The normal, or wild-type, pattern is arginine-16-glycine and glutamine-27-glutamic acid, but SNPs have been described with
homozygous pairing (e.g., Gly16Gly, Arg16Arg, Glu27Glu, and
Gln27Gln). The frequency of these polymorphisms is the same in the
normal population as in asthmatics. Presence of a gene variant itself
does not appear to influence baseline lung function.